Might give some thought to Webroots "SpySweeper"
I've used it for about two years and never had problems with spyware or pop-ups since. And if the market for something like Advanced System Optimizer .... at HermanSt.com, it comes with a FREE copy of SpySweeper (not a demo or crippled version).
"Advanced System Optimizer v2 is a powerful, easy-to-use system performance and optimization suite. Its 30+ tools let you supercharge your PC's performance. You can enhance your security, beautify and optimize Windows, tweak Windows settings, customize your screens, and make Windows work the way you want it to.
* Optimization Tools Get the best output from your PC
* PC Fix-Up & Information Tools Improve system settings and optimize system performance
* System Cleanup Tools Remove unnecessary data and files from your PC
* Security Tools Protect privacy and secure sensitive information
* Maintenance Tools Enhance system performance and increase usability
* Tools to Beautify Windows Create your favorite PC look