are programs that actually run a requested function or operation via a simultaneous key press on the keyboard.
Example: Alt+N = Next item to find in a text search.
All Asus does is enable you to use a key press shortcut that is specialised and unique to that program. Have a look at the help section in Asus to see what this is. Other programs often come with a hotkey app just so you know. MS Word is a good example of this.
If file is located where expected, nothing to worry about; false positive alert by MSE or whatever a/v you run.