I have the same tv and found the best picture settings!

by the2kings - 5/5/12 3:13 PM

In Reply to: Vizio E421VL settings? by Tomwalla

1. Reset your tv settings by going to menu and help.
2. Change the Screen Aspect Ratio to Wide
3. Go to picture and change picture mode to Vivid
4. Go to picture and then More and then color temperature and change it to Normal
5. Advanced Picture Settings:

*Smooth Motion Effect - Medium
*Real Cinema Mode - Precision
*Noise Reduction - Low
*MPEG NR - Low
*Color Enhancement - Rich Color
*Adaptive Luma - Strong
*Film Mode - Auto
*Backlight Control - Off
*Ambient Light Sensor - Off