This is the response I get

This is the response I get when I try and click on the drive to open it...

F:\ refers to a location that is unavailable. It could be on a hard drive on this computer or on a network. Check to make sure that the disk is properly inserted, or that you are connected to the internet (which I am always connected) and then try again. If it still cannot be located, the information might have been moved to a different location.

1. What other location can there be if this drive does not show up in disk management?
2. Where could this setting be so I can possibly change it?
3. I have tried all the USB ports on my computer and with different USB cables so that is not the problem.