Before an antivirus, I'd recommend ditching Explorer for Firefox. Right off the bat, block mediaplex, maxserving, 2o7 and casalemedia.
Ccleaner.exe. is god. It renders Spybot NEARLY pointless and it deletes programs & applications most folks thought they deleted months ago. It addresses registry, temp files, startup, running programs, cookies, cache, history, even the cache of java and Real Player. In essence, if run at start-up and after every session, it's more likely to delete any virus you may have picked up. Aside form viruses, if Real Player's cache isn't deleted, it can build up and take lots of space.... relatively 'speaking'. CCleaner is free and easy to use.
In addition, I use Spybot & Spyware blaster to render MS Explorer completely crippled as many other MS programs are designed to use Explorer to update. These programs can lock Explorers options from being modified w/in the brower and they can lock the start-up page. Spybot also has a resident which actively guards EVERY registry modification. Spybot & Spyware Blaster are both free and easy to use.
NoAdHosts is also a free program which is downloaded once and prevents banners in the likes of Hotmail from even appearing. Once downloaded, it never needs to be run.
Of course an anti-virus which is programmed to update and run as well as a firewall.
Finally, scroll through your cookies from time to time and Google some of them. Then selectively block the ones you don't find savory.
This may sound like a lot of work, but really it's not. Most programs can be programmed to update and run on their own. The rest becomes as much habit as signing on to Yahoo or Hotmail. The only program I actively run is CCleaner. Just one.
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