Do you have more than 1 optical drive, and
is the problem drive the drive you used to install the game? I have 2 optical drives, and normally install from the D drive. Sometimes, if I accidently put the disk in the other drive (a DVD burner), the game doesn't auto-start- I don't get the error message you get, however. I think (guessing here) something in the registry says, "you installed me from here, so you should play from here."
Aside from that, as I believe was suggested to you, remove ALL optical drives from device manager, but do it from within safe-mode, reboot, and pray. Have you checked the jumpers, BIOS?
And lastly, I don't think you answered Bob's question- did you install the motherboard drivers? Look for updates for mobo drivers from maker's website? Is your disk damaged, scratched? If so, possibly a cleaning will help, and Bob's suggestion of getting an optical drive cleaner may help. Oh, I just remembered somethin when I had a drive that wouldn't respond- I got a flashlight and took a peek inside; there was some paper from a custom disk I made with a stick on label. Apparently some of the paper shredded off, I used plastic tweezers to pull the paper out. Problem solved.
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