You will eventually need to reboot your PC
There is no "physical" reason for having to reboot your PC periodically. Except for the normal wear and tear nothing should physically prevent you from doing so. But, there is a thing most of us forget. The accuracy of the information residing in your RAM while the PC is operating is (extremelly) crucial for the health of your PC. Have you asked yourself why do "official" servers come with ECC and sometimes Buffered RAM? The reason is simple, in order for a PC to survive 24/7 you have to make sure what is in RAM will stay uncorrupted. Now, why could the information in RAM become corrupted? I have read in computer related journals that besides the ever present power line noise even minute environmental radiation will eventually corrupt your RAM. Even radiation coming from outer space (cosmic radiation) will also eventually corrupt RAM content. ECC RAM can correct changes in RAM content not made by the OS or the application you are running. Also, Buffered RAM will help in the trasnfer of data between the RAM modules and the Memory controller chip when there are large amounts of RAM. In simple words, RAM content accuracy will determine how long will your PC keep going without a reboot. So, you need a reliable 24/7 PC?, use a PC with ECC RAM.
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