Windows 7 forum: Windows 7 Mouse/Keyboard hangs?

I'm seeming randomly having a problem on my self-built desktop PC where my keyboard and mouse will freeze up, leaving the computer virtually inoperable. I also get strange hangs in the mouse that last a second or so, leading up to one big hang. There's no BSOD or anything like that.

I have to hard reboot in order to do anything. All programs and services continue to run and there's no real warning. Games will continue to play like normal as will videos and music, I just can't alt/tab or Cntrl/Alt/Delete. There's no indication that the devices disconnected physically or otherwise. The LEDs on the keyboard stay lit, so it's not as if it loses power.

I have tried unplugging and replugging, updating USB drivers, installing and subsequently uninstalling Logitech software, and physically cleaning the fan (Just to ensure heat wasn't a factor). I've ran virus checks from Avast and Malware Bytes that have come back clean. I've looked into the event viewer, but I'm not very proficient with it and I can't seem to find anything on it.

Any advice?

Mainboard : Gigabyte Z68A-D3H-B3
Chipset : Intel Z68
Processor : Intel Core i5 2500K @ 3300 MHz
Physical Memory : 4096 MB (2 x 2048 DDR3-SDRAM )
Video Card : AMD Radeon HD 6900 Series
Hard Disk : M4-CT128M4SSD2 ATA Device (128GB)
Hard Disk : SAMSUNG HD103SJ ATA Device (1000GB)
Hard Disk : Seagate Expansion Desk (3001GB)
DVD-Rom Drive : ASUS DRW-24B1ST a
CD-Rom Drive : DTSOFT Virtual CdRom Device
Monitor Type : Acer P215H - 22 inches
Monitor Type : Dell Computer DELL E193FP - 19 inches
Network Card : Realtek Semiconductor RTL8168/8111 PCIe Gigabit Ethernet Adapter
Network Card : Ralink Technology RT2760 802.11n Wireless LAN Card
Operating System : Windows 7 Ultimate Professional Media Center 6.01.7601 Service Pack 1 (64-bit)
DirectX : Version 11.00
Windows Performance Index : 7.4 on 7.9
Logitech M-U0007 Wired Mouse
AVS Multimedia LED Keyboard W9868