Computer help: Weird boot issue

Weird boot issue

I recently put together a new tower, and it ran great for a few days, but it now has a weird problem I haven't come across before. Before I get into it, this is my system:

Asus P5N-T Deluxe 780i
Intel Core 2 Duo E6850
2GB OCZ (OCZ2T1066IO2GK) DDR2 PC2-8500 Titanium
Galaxy GeForce 8800GTS
Western Digital Caviar 250GB SATAII (MAIN DRIVE)
Seagate Barracuda (ST3500320AS) 7200.11 SATA NCQ 3.0Gb/s 500GB 32MB Cache
Western Digital Caviar 40GB EIDE
ASUS DRW-2014L1T SATA LightScribe
OCZ (OCZ700GXSSLI) GameXStream 700 Watt Power Supply
XP Home

The problem is this, my rig has developed a problem where it will not boot up without going to BSOD unless I have one of a few different kinds of disks in the DVD drive. I first discovered it would boot properly with the motherboard support disk in, then the driver disk for the graphics card, I also found it boots up fine with the XP disk in the drive, I'm betting that some other similar type disks will work. What will not work are blank disks or disks with only video or word files etc. If I eject the disk after everything is fully loaded sometimes I am fine, but more often then not immediately after ejecting the disk in the DVD drive the system crashes to BSOD and reboots.

The error message on the BSOD is:
Driver IRQL Not Less or Equal

I checked the IRQL list and there are no conflicts, nothing appears to be overloaded, not to mention, the disk in the drive fixes the BSOD issue. I have updated the BIOS, made sure the C drive is the boot drive, uninstalled and reinstalled drivers for the board and graphics card, all with the same result: disk in drive, no BSOD, no disk in drive BSOD. I have used all the newest drivers and I have used all the default drivers on the support disks that have come with the hardware all with the same result. With a support disk or XP in the drive everything runs smooth as silk, as soon as the disk is ejected, BSOD!

Anyone with an idea how to solve this please respond! I would like to have back the normal use of my DVD drive again as opposed to being stuck with a support disk in it all the time!